Endocrine Abstracts

Background: Risk of developing papillary thyroid carcinoma (PTC), the most frequent thyroid malignancy, is elevated up to 8.6-fold in the first-degree relatives of PTC patients, what could be explained by polygenic action of low-penetrance alleles. Since the DNA-damaging exposure to ionizing radiation is a known risk factor for thyroid cancer, polymorphisms in DNA repair genes are likely to affect this risk. Among the DNA repair proteins, the ATM–CHEK2–BRCA1 axis see...

Introduction: Multifocal papillary thyroid microcarcinama (PTmC) has been considered as more aggressive than the unifocal one.Aim of the study: This paper aims to compare this two groups considering histopatological sign of aggressivity, presence of inflammation and radioiodine uptake.Materials and methods: The analysis concerned 81 patient with microcarcinoma (PTmC) selected from group of 961 (8%) diagnosed and treated in conventi...

Objectives: Papillary thyroid carcinoma (PTC) is the most common malignancy of the endocrine system. Its heritability is the highest among common cancers, as evidenced by family-based studies. Thyroid hormone receptor β gene (THRB), a known tumor suppressor, is crucial for the proper thyroid function, therefore its polymorphisms are likely to affect the risk for thyroid cancer.Aim of the study: In order to identify alleles that might modify...